Why do you have to marry the two? 
The idea and thesis of long term margin of safety based investment is completely different from momentum investing ( whether quant based or otherwise).
In momentum or quant based investing you are trying to buy and sell in usually a defined timeframe. The risk management is done by using stop losses and position sizing.
If you want to buy and hold for a longer period, you are looking for a margin of safety. That can come from buy price (cheapness), balance sheet strength, business quality, management quality, growth etc.
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